Topical Finasteride: Science, Pros and Cons and Practical Tips

Topical Finasteride: Science, Pros and Cons and Practical Tips

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In today’s video we’re going to discuss topical finasteride – a topic that is not widely known in the hair loss community. Watch the full video to find out more about this rarely discussed topic!

Reference Links:

https://pdfs.semanticscholar.org/a669/2a473a3e6ee74f92d5384b5ba55508d17376.pdf

https://www.researchgate.net/profile/Maurizio_Caserini/publication/285733679_Effects_of_a_novel_finasteride_025_topical_solution_on_scalp_and_serum_dihydrotestosterone_in_healthy_men_with_androgenetic_alopecia/links/5694fea508ae3ad8e33d3e48.pdf

Timestamps:
0:32 – Intro
0:58 – Intro on Minoxidil and oral Finasteride
2:18 – Topical Finasteride and scientific studies
4:40 – Standard oral version Vs topical
5:53 – Topical Finasteride conclusion
7:15 – How to make topical Finasteride
8:15 – Outro

Full Transcript:

Hey guys Leon here from Hairguard.com, where people who are worried about their hair loss go to regrow their hair.

Today we’ll be looking at topical finasteride, which some of you may have heard of, but is generally not a widely known or discussed topic.

We’ll explain the idea behind topical finasteride and review the relevant research, highlighting the pros and cons.

And, if you’re interested in trying it out for your own hair loss, we’ll also give you some tips on how to make it.

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Now without any further delay let’s dive straight into it.

For the past three decades or so, the only FDA-approved medications for male pattern baldness have been topical minoxidil and oral finasteride.

You see, when the FDA approves a new drug, it doesn’t just approve the chemical compound per se.

It actually approves a specific route of administration, be it oral, topical or whatever. It also approves a specific dosage.

So for male pattern baldness, finasteride is approved, manufactured and sold for oral use only. In the form of a 1mg pill, to be taken once daily.

Now the advantages of an oral over a topical hair loss treatment are obvious.

Rather than messing with your hair and having to wait for it to dry, you just pop a pill, and you’re done. End of story.

So in terms of user friendliness, finasteride is clearly superior to minoxidil. Regardless of whether you compare it to minoxidil’s original liquid version, or the more recent mousse.
But the mega disadvantage of finasteride also boils down to its being a pill.

The pill is dissolved in the stomach and absorbed into the bloodstream. It then makes its way all throughout the body, and reaches every single tissue.

But you’re really only interested in getting it to the hair follicles.

It’s this systemic absorption that is partly responsible for the nasty side effects, which include impotence, loss of libido and gynecomastia.

So what if you could make a topical version of finasteride?

One that inhibits DHT on the scalp, while being minimally absorbed in the bloodstream.
You could, theoretically, get most of the benefits while avoiding many of the side effects.
Luckily for us, there are at this point some studies on this.

The two main questions that these studies have asked are
a) is topical finasteride absorbed into the bloodstream less than the pill form?
and b) is it as effective?

So let’s look at the first question, which was the subject of a 2014 study out of Italy.

That study compared blood finasteride levels in men who were receiving either a topical 0.25% liquid solution of finasteride or the standard 1mg daily pill.

Both groups were treated for 7 days.

And blood concentrations of finasteride were indeed found to be substantially lower in the topical group.

On average, the topical finasteride group had a maximum blood plasma concentration of 0.46ng/ml, compared to 6.86 for the oral treatment group. This was a roughly 15-fold difference.

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Disclaimer

This video is for educational purposes only and is not intended to treat, diagnose or cure any disease.

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